The ratio of N-acetyl aspartate to glutamate correlates with disease duration of amyotrophic lateral sclerosis.

@article{Sako2016TheRO,
  title={The ratio of N-acetyl aspartate to glutamate correlates with disease duration of amyotrophic lateral sclerosis.},
  author={Wataru Sako and Takashi Abe and Yuishin Izumi and Masafumi Harada and Ryuji Kaji},
  journal={Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia},
  year={2016},
  volume={27},
  pages={110-3}
}
Glutamate (Glu)-induced excitotoxicity has been implicated in the neuronal loss of amyotrophic lateral sclerosis. To test the hypothesis that Glu in the primary motor cortex contributes to disease severity and/or duration, the Glu level was investigated using MR spectroscopy. Seventeen patients with amyotrophic lateral sclerosis were diagnosed according to the El Escorial criteria for suspected, possible, probable or definite amyotrophic lateral sclerosis, and enrolled in this cross-sectional… CONTINUE READING
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