The ratio of +/-KTS splice variants of the Wilms' tumour suppressor protein WT1 mRNA is determined by an intronic enhancer.

@article{Yang2008TheRO,
  title={The ratio of +/-KTS splice variants of the Wilms' tumour suppressor protein WT1 mRNA is determined by an intronic enhancer.},
  author={Cheng Wei Tony Yang and Paul J. Romaniuk},
  journal={Biochemistry and cell biology = Biochimie et biologie cellulaire},
  year={2008},
  volume={86 4},
  pages={312-21}
}
Alternative splicing of the primary transcript of the Wilms' tumour suppressor gene WT1 involving 2 overlapping 5' splice sites at the end of exon 9 results in the insertion of 2 amino acids (KTS) between zinc fingers 3 and 4 of the protein. The presence or absence of these 3 amino acids has consequences for DNA binding affinity, protein-protein… CONTINUE READING