The rate of protein synthesis in hematopoietic stem cells is limited partly by 4E-BPs.

  title={The rate of protein synthesis in hematopoietic stem cells is limited partly by 4E-BPs.},
  author={Robert A J Signer and Le Qi and Zhiyu Zhao and David R. M. Thompson and Alla A. Sigova and Z. P. Fan and George N Demartino and Richard A. Young and Nahum Sonenberg and Sean J Morrison},
  journal={Genes & development},
  volume={30 15},
Adult stem cells must limit their rate of protein synthesis, but the underlying mechanisms remain largely unexplored. Differences in protein synthesis among hematopoietic stem cells (HSCs) and progenitor cells did not correlate with differences in proteasome activity, total RNA content, mRNA content, or cell division rate. However, adult HSCs had more hypophosphorylated eukaryotic initiation factor 4E-binding protein 1 (4E-BP1) and 4E-BP2 as compared with most other hematopoietic progenitors… CONTINUE READING


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