The rate of protein secretion dictates the temporal dynamics of flagellar gene expression.

@article{Brown2008TheRO,
  title={The rate of protein secretion dictates the temporal dynamics of flagellar gene expression.},
  author={Jonathon D. Brown and Supreet Saini and C. Aldridge and Jenny A. Herbert and Christopher V. Rao and Phillip D Aldridge},
  journal={Molecular microbiology},
  year={2008},
  volume={70 4},
  pages={924-37}
}
Flagellar gene expression is temporally regulated in response to the assembly state of the growing flagellum. The key mechanism for enforcing this temporal hierarchy in Salmonella enterica serovar Typhimurium is the sigma(28)-FlgM checkpoint, which couples the expression of the late flagellar (P(class3)) genes to the completion of the hook-basal body. This checkpoint is triggered when FlgM is secreted from the cell. In addition to the sigma(28)-FlgM checkpoint, a number of other regulatory… CONTINUE READING