The rate of molecular evolution considered from the standpoint of population genetics.

  title={The rate of molecular evolution considered from the standpoint of population genetics.},
  author={Motoo Kimura},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={63 4},
  • M. Kimura
  • Published 1 August 1969
  • Biology
  • Proceedings of the National Academy of Sciences of the United States of America
The rate of amino acid substitutions in the evolution of homologous proteins is remarkably constant. Furthermore, estimated rates of amino acid substitutions based on comparisons of the alpha hemoglobin chains of various mammals with that of the carp are about the same as those based on comparisons of the carp alpha and mammalian beta or the alpha and beta chains in mammals. These uniformities are regarded as evidence for the hypothesis that a majority of amino acid substitutions that occurred… 

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