The rate of free radical production as a determinant of the rate of aging: evidence from the comparative approach

@article{PrezCampo1998TheRO,
  title={The rate of free radical production as a determinant of the rate of aging: evidence from the comparative approach},
  author={R. P{\'e}rez-Campo and M. L{\'o}pez-Torres and S. Cadenas and C. Rojas and G. Barja},
  journal={Journal of Comparative Physiology B},
  year={1998},
  volume={168},
  pages={149-158}
}
Abstract The relationship of oxidative stress with maximum life span (MLSP) in different vertebrate species is reviewed. In all animal groups the endogenous levels of enzymatic and non-enzymatic antioxidants in tissues negatively correlate with MLSP and the most longevous animals studied in each group, pigeon or man, show the minimum levels of antioxidants. A possible evolutionary reason for this is that longevous animals produce oxygen radicals at a low rate. This has been analysed at the… Expand
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