The rate of absorption and relative bioavailability of caffeine administered in chewing gum versus capsules to normal healthy volunteers.

@article{Kamimori2002TheRO,
  title={The rate of absorption and relative bioavailability of caffeine administered in chewing gum versus capsules to normal healthy volunteers.},
  author={G. Kamimori and C. S. Karyekar and R. Otterstetter and D. Cox and T. Balkin and G. Belenky and N. D. Eddington},
  journal={International journal of pharmaceutics},
  year={2002},
  volume={234 1-2},
  pages={
          159-67
        }
}
OBJECTIVE The purpose of this study was to evaluate the rate of absorption and relative bioavailability of caffeine from a Stay Alert chewing gum and capsule formulation. METHODS This was a double blind, parallel, randomized, seven treatment study. The treatment groups were: 50, 100, and 200 mg gum, 50, 100, and 200 mg capsule, and a placebo. Subjects consisted of 84 (n=12 per group); healthy, non-smoking, males who had abstained from caffeine ingestion for at least 20 h prior to dosing and… Expand
234 Citations
Administration of Caffeine in Alternate Forms
  • 36
  • PDF
Effects of time-release caffeine containing supplement on metabolic rate, glycerol concentration and performance.
  • 9
  • Highly Influenced
  • PDF
Design, formulation and evaluation of caffeine chewing gum
  • 12
  • Highly Influenced
Low-Dose Caffeine Administered in Chewing Gum Does Not Enhance Cycling to Exhaustion
  • 23
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 16 REFERENCES
Relative bioavailability of aspirin gum.
  • 31
Caffeine disposition after oral doses
  • 328
Dose‐Dependent Pharmacokinetics and Psychomotor Effects of Caffeine in Humans
  • 291
Relative bioavailability of methadone hydrochloride administered in chewing gum and tablets.
  • 13
Dose-dependent caffeine pharmacokinetics during severe sleep deprivation in humans.
  • 35
Effect of three caffeine doses on plasma catecholamines and alertness during prolonged wakefulness
  • 69
Bioavailability of two formulations of acetylsalicylic acid gums.
  • 11
Determinants of nicotine intake while chewing nicotine polacrilex gum
  • 175
Behavioral Effects of Caffeine
  • 68
Chewing can relieve sleepiness in a night of sleep deprivation.
  • D. Hodoba
  • Medicine
  • Sleep research online : SRO
  • 1999
  • 20
  • PDF
...
1
2
...