The rate of absorption and relative bioavailability of caffeine administered in chewing gum versus capsules to normal healthy volunteers.

@article{Kamimori2002TheRO,
  title={The rate of absorption and relative bioavailability of caffeine administered in chewing gum versus capsules to normal healthy volunteers.},
  author={Gary H. Kamimori and Chetan S Karyekar and Ronald Otterstetter and Donna S. Cox and Thomas J. Balkin and Gregory Lucas Belenky and Natalie D. Eddington},
  journal={International journal of pharmaceutics},
  year={2002},
  volume={234 1-2},
  pages={
          159-67
        }
}
OBJECTIVE The purpose of this study was to evaluate the rate of absorption and relative bioavailability of caffeine from a Stay Alert chewing gum and capsule formulation. METHODS This was a double blind, parallel, randomized, seven treatment study. The treatment groups were: 50, 100, and 200 mg gum, 50, 100, and 200 mg capsule, and a placebo. Subjects consisted of 84 (n=12 per group); healthy, non-smoking, males who had abstained from caffeine ingestion for at least 20 h prior to dosing and… CONTINUE READING

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