The rate-limiting step in the folding of a large ribozyme without kinetic traps.

@article{Fang2002TheRS,
  title={The rate-limiting step in the folding of a large ribozyme without kinetic traps.},
  author={X. W. Fang and Pappannan Thiyagarajan and Tobin R. Sosnick and Tao Pan},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2002},
  volume={99 13},
  pages={8518-23}
}
A fundamental question in RNA folding is the nature of the rate-limiting step. Folding of large RNAs often is trapped by the need to undo misfolded structures, which precludes the study of the other, potentially more interesting aspects in the rate-limiting step, such as conformational search, metal ion binding, and the role of productive intermediates. The catalytic domain of the Bacillus subtilis RNase P RNA folds without a kinetic trap, thereby providing an ideal system to elucidate these… CONTINUE READING

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