The rat phospholipase C beta 4 gene is expressed at high abundance in cerebellar Purkinje cells.


Inositol phospholipid-specific phospholipase C (PLC) generates two important second messengers, inositol triphosphate and diacylglycerol. The recently cloned rat PLC beta 4 cDNA is highly homologous to the norpA cDNA of Drosophila melanogaster. We have mapped the PLC beta 4 gene expression in rat brain tissue sections by in situ hybridization. The PLC beta… (More)


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