The rat model of tardive dyskinesia: relationship between vacuous chewing movements and gross motor activity during acute and long-term haloperidol treatment.

@article{Andreassen1995TheRM,
  title={The rat model of tardive dyskinesia: relationship between vacuous chewing movements and gross motor activity during acute and long-term haloperidol treatment.},
  author={Ole A. Andreassen and Hugo Arild J\orgensen},
  journal={Life sciences},
  year={1995},
  volume={57 24},
  pages={2263-72}
}
Tardive dyskinesia (TD) is a serious side-effect of neuroleptic treatment. In order to describe and analyse more thoroughly the rat model of TD, the behavior of the rats during cage testing was studied after acute and during long-term haloperidol (HAL) treatment. Rats were injected with HAL i.p. in an acute experiment, and in a long-term experiment, rats were treated for 4-12 months with HAL decanoate IM. Control rats received saline or sesame oil. The behavior was videotaped one h after the i… CONTINUE READING