The rat intervertebral disk degeneration pain model: relationships between biological and structural alterations and pain

@inproceedings{Kim2011TheRI,
  title={The rat intervertebral disk degeneration pain model: relationships between biological and structural alterations and pain},
  author={Jae-Sung Kim and Jeffrey S. Kroin and X Allen Li and Howard S. An and Asokumar Buvanendran and Dongyao Yan and Kenneth J. Tuman and Andre J van Wijnen and Di Chen and Hee-Jeong Im},
  booktitle={Arthritis research & therapy},
  year={2011}
}
INTRODUCTION Degeneration of the interverterbral disk is as a cause of low-back pain is increasing. To gain insight into relationships between biological processes, structural alterations and behavioral pain, we created an animal model in rats. METHODS Disk degeneration was induced by removal of the nucleus pulposus (NP) from the lumbar disks (L4/L5 and L5/L6) of Sprague Dawley rats using a 0.5-mm-diameter microsurgical drill. The degree of primary hyperalgesia was assessed by using an… CONTINUE READING
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