The rat glucocorticoid receptor mutant K461A differentiates between two different mechanisms of transrepression.

@article{Meyer1997TheRG,
  title={The rat glucocorticoid receptor mutant K461A differentiates between two different mechanisms of transrepression.},
  author={Tobias Meyer and D B Starr and Jan Carlstedt-Duke},
  journal={The Journal of biological chemistry},
  year={1997},
  volume={272 34},
  pages={21090-5}
}
The glucocorticoid receptor (GR) can both activate and repress transcription of target genes by interaction with specific genomic response elements, glucocorticoid response elements (GREs). Activation of transcription is usually the result of the direct interaction between GR and the GRE, whereas GR-mediated transcription repression is either the result of the indirect action of GR, mediated by a response element as a result of protein.protein interaction or by an occlusion mechanism in which… CONTINUE READING