The rat endometrial adenocarcinoma cell line RUCA-I: a novel hormone-responsive in vivo/in vitro tumor model.

@article{Vollmer1996TheRE,
  title={The rat endometrial adenocarcinoma cell line RUCA-I: a novel hormone-responsive in vivo/in vitro tumor model.},
  author={Guenter Vollmer and Martin R. Schneider},
  journal={The Journal of steroid biochemistry and molecular biology},
  year={1996},
  volume={58 1},
  pages={103-15}
}
The recently established, estrogen receptor positive rat endometrial adenocarcinoma cell line RUCA-I was tested for estrogen responsiveness in vivo and in vitro. In vivo, 10(6) RUCA-I cells were injected subcutaneously into intact, ovariectomized, or ovariectomized, estradiol-substituted syngenic DA/Han rats. All animals developed well differentiated endometrial adenocarcinoma, that had metastasized to peripheral lymph nodes and into the lung. Ovariectomy reduced tumor and lymph node weight, as… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-8 of 8 extracted citations

Issues to be considered when studying cancer in vitro.

Critical reviews in oncology/hematology • 2013
View 1 Excerpt

Similar Papers

Loading similar papers…