The rat androgen-binding protein (ABP/SHBG) gene contains triplet repeats similar to unstable triplets: Evidence that the ABP/SHBG and the fragile X-related 2 genes overlap

@article{Joseph1998TheRA,
  title={The rat androgen-binding protein (ABP/SHBG) gene contains triplet repeats similar to unstable triplets: Evidence that the ABP/SHBG and the fragile X-related 2 genes overlap},
  author={David R. Joseph},
  journal={Steroids},
  year={1998},
  volume={63},
  pages={2-4}
}
View on Elsevier
doi.org
17 Citations
Background Citations
1

17 Citations

Citation Type

Citation Type

Human sex hormone-binding globulin gene expression- multiple promoters and complex alternative splicing
TLDR
It is reported that transcriptional expression of the human SHBG gene is far more complex than previously described, and new and important questions are raised regarding the role of novel alternatively spliced transcripts, their function in hormonally responsive tissues including the breast and prostate, and the role that aberrant SH BG gene expression may play in cancer.
Five different genes, Eif4a1, Cd68, Supl15h, Sox15 and Fxr2h, are clustered in a 40 kb region of mouse chromosome 11.
Identification, characterization and expression of novel Sex Hormone Binding Globulin alternative first exons in the human prostate
TLDR
The identification of multiple transcription start sites (TSS) upstream of the annotated first exon of human SHBG, and the detection of the alternative transcripts in human prostate, concur with the prediction of the ENCODE (ENCyclopedia of DNA Elements) project, and suggest that the regulation of SHBG is much more complex than previously reported.
Genomic organization of an intron-containing sperm protein 17 gene (Sp17-1) and an intronless pseudogene (Sp17-2) in humans: a new model.
NF-Y, AP2, Nrf1 and Sp1 regulate the fragile X-related gene 2 (FXR2).
TLDR
To understand the regulation of the human FXR2 gene, cloned the evolutionarily conserved region upstream of theFXR2 translation start site and showed that it also has bidirectional promoter activity in both neuronal and muscle cells as evidenced by luciferase reporter assay studies.
Origin of gene overlap: the case of TCP1 and ACAT2.
TLDR
The results reveal that the overlap apparently arose during the transition from therapsid reptiles to mammals and has been retained for >200 million years.
Comparative genomic sequence analysis of the FXR gene family: FMR1, FXR1, and FXR2.
TLDR
The genomic structures of the mouse and human genes FMR1, FXR1, and FXR2 are described and compared, suggesting they are derived from a common ancestral gene.
Androgen-Binding Protein
TLDR
These immunocytochemical results confirm that ABP synthesized and secreted by Sertoli cells in the testis is transported to the epididymal duct via testicular fluid and is taken up by epithelial cells of the proximal segments.
Newly identified exons encoding novel variants of p94/calpain 3 are expressed ubiquitously and overlap the α‐glucosidase C gene
Physical map of 17p13 and the genes adjacent to p53.
TLDR
Limited analysis of primary human colon tumors, hemizygous for the p53 gene, indicates loss of the entire 1.1-Mb region upon deletion of wildtype p53.
...
...

References

SHOWING 1-10 OF 13 REFERENCES
Identification of an alternate promoter in the rat androgen-binding protein/sex hormone-binding globulin gene that regulates synthesis of a messenger RNA encoding a protein with altered function.
TLDR
The P1 transcriptional start site in testis and fetal liver was confirmed and an alternate promoter (PA) in the ABP/SHBG gene located 15 kilobases up-stream from the previously characterized testicular promoter (P1), has the characteristics of a GC-rich housekeeping-type promoter.
The human sex hormone-binding globulin gene contains exons for androgen-binding protein and two other testicular messenger RNAs.
TLDR
Southern blots of human placental DNA and cloned genomic DNA fragments indicate that sex hormone-binding globulin (SHBG) and its related testicular cDNAs are the products of a single gene.
The gene structure of rat androgen-binding protein: identification of potential regulatory deoxyribonucleic acid elements of a follicle-stimulating hormone-regulated protein.
TLDR
Southern blot analysis of rat genomic DNA indicated that there is a single gene for ABP in the rat, which supports the idea that sex hormone binding globulin produced by fetal rat liver is coded by the same gene.
Alternative processing of androgen-binding protein RNA transcripts in fetal rat liver. Identification of a transcript formed by trans splicing.
Genetic mapping of the gene for androgen-binding protein/sex hormone-binding globulin to mouse chromosome 11.
TLDR
Southern blot analysis of DNAs from Chinese hamster x mouse and rat x mouse somatic cell hybrids showed that the mouse gene encoding androgen-binding protein/sex hormone-binding globulin (ABP-SHBG) is on Chromosome 11, and is closely linked to several neurological mutations.
Localization of the human sex hormone-binding globulin gene (SHBG) to the short arm of chromosome 17 (17p12----p13).
TLDR
Two separate cDNA probes corresponding to the 5' and 3' portions of the coding sequence for SHBG have been hybridized to human metaphase chromosomes in situ and the SHBG gene has been localized to the p12----p13 bands of chromosome 17.
A potential splicing factor is encoded by the opposite strand of the trans-spliced c-myb exon.
TLDR
It is reported that a putative splicing factor (PR264) is encoded by the opposite strand of the c-myb trans-spliced exon, and that the relative proportion of the PR264 transcripts is developmentally regulated in chicken.
The fragile X mental retardation syndrome protein interacts with novel homologs FXR1 and FXR2.
TLDR
Cloned and sequenced a protein that interacts tightly with FMR1 in vivo and in vitro, and it is likely that FXR1 and FXR2 are likely to play important roles in the function of F MR1 and in the pathogenesis of the Fragile X Mental Retardation Syndrome.
Variation of the CGG repeat at the fragile X site results in genetic instability: Resolution of the Sherman paradox
Two mammalian genes transcribed from opposite strands of the same DNA locus.
TLDR
The characterization of a genomic locus in the rat that encodes overlapping genes occupying both strands of the same piece of DNA, which encodes gonadotropin-releasing hormone and SH, is described.
...
...