The rapid formation of inositol phosphates in human platelets by thrombin is inhibited by prostacyclin.

@article{Watson1984TheRF,
  title={The rapid formation of inositol phosphates in human platelets by thrombin is inhibited by prostacyclin.},
  author={Stephanie Watson and RANDY T. MCCONNELL and Eduardo G. Lapetina},
  journal={The Journal of biological chemistry},
  year={1984},
  volume={259 21},
  pages={13199-203}
}
The biochemical events underlying the ability of thrombin to enhance the metabolism of inositol phospholipids in human platelets have been investigated using platelets prelabeled with [3H]inositol. Thrombin treatment caused rapid formation of radioactive inositol monophosphate (IP), inositol bisphosphate (IP2), and inositol trisphosphate (IP3) with less marked and more variable changes in the levels of radioactive inositol phospholipids. Formation of IP2 and IP3 could be detected 5 s after… CONTINUE READING
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