The rapid expression of myocardial hsp 70 mRNA and the heat shock 70 kDa protein can be achieved after only a brief period of retrograde hyperthermic perfusion.

@article{McCully1995TheRE,
  title={The rapid expression of myocardial hsp 70 mRNA and the heat shock 70 kDa protein can be achieved after only a brief period of retrograde hyperthermic perfusion.},
  author={James D McCully and Truls Myrmel and Margaret M. Lotz and Irvin B. Krukenkamp and Sidney Levitsky},
  journal={Journal of molecular and cellular cardiology},
  year={1995},
  volume={27 3},
  pages={873-82}
}
The induction of heat shock proteins in the myocardium has been suggested as a possible intervention to allow for enhanced cardioprotection. We have postulated that a brief period of retrograde hyperthermic perfusion would be sufficient to induce Hsp 70 mRNA and protein accumulation. To investigate this hypothesis, rat hearts (n = 45) were perfused at 37 degrees C for 30 min, then perfused for 15 min at 42 degrees C, and allowed to recover at 37 degrees C for 120 min. Control hearts (n = 23… CONTINUE READING

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