The rainbow trout metallothionein-B gene promoter: contributions of distal promoter elements to metal and oxidant regulation.

@article{Samson2001TheRT,
  title={The rainbow trout metallothionein-B gene promoter: contributions of distal promoter elements to metal and oxidant regulation.},
  author={Stephen L. Samson and Wendy J. Paramchuk and L. Gedamu},
  journal={Biochimica et biophysica acta},
  year={2001},
  volume={1517 2},
  pages={
          202-11
        }
}
In this report, the contributions of the distal 5'-regulatory sequences of the rainbow trout (Oncorhynchus mykiss) metallothionein (tMT)-B gene promoter (-738 to +5) were studied. Transfection of the -738 promoter fragment in a rainbow trout hepatoma cell line (RTH-149) resulted in 4- to 5-fold greater activity compared to the proximal -137 promoter region. Mutation of the proximal MREa abolishes the basal activity of the -738 fragment indicating that the distal regulatory elements require a… CONTINUE READING

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