The rainbow trout (Oncorhynchus mykiss) tumor model: recent applications in low-dose exposures to tumor initiators and promoters.

@article{William2003TheRT,
  title={The rainbow trout (Oncorhynchus mykiss) tumor model: recent applications in low-dose exposures to tumor initiators and promoters.},
  author={David E William and George S. Bailey and Ashok Reddy and Jerry D. Hendricks and Aram Oganesian and Gayle A. Orner and Cliff B. Pereira and James A. Swenberg},
  journal={Toxicologic pathology},
  year={2003},
  volume={31 Suppl},
  pages={58-61}
}
The rainbow trout has been utilized as a model for human carcinogenesis for a number of years. Trout are relatively inexpensive to maintain and exhibit (over the 9-12-month tumor assay period) very low spontaneous tumor backgrounds. One of the most powerful applications of this model is the design and conduct of large-scale tumor studies requiring thousands of animals that address statistically challenging questions of dose-response. Two recent examples of such applications include our studies… CONTINUE READING