The radiotherapeutic injury--a complex 'wound'.

  title={The radiotherapeutic injury--a complex 'wound'.},
  author={James Denham and Martin Hauer-Jensen},
  journal={Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology},
  volume={63 2},
Radiotherapeutic normal tissue injury can be viewed as two simultaneously ongoing and interacting processes. The first has many features in common with the healing of traumatic wounds. The second is a set of transient or permanent alterations of cellular and extracellular components within the irradiated volume. In contrast to physical trauma, fractionated radiation therapy produces a series of repeated insults to tissues that undergo significant changes during the course of radiotherapy… CONTINUE READING