The radiosensitizing effect of metronidazole and misonidazole (Ro-07-0582) on a human malignant melanoma grown in the athymic mutant nude mouse.

@article{Rofstad1978TheRE,
  title={The radiosensitizing effect of metronidazole and misonidazole (Ro-07-0582) on a human malignant melanoma grown in the athymic mutant nude mouse.},
  author={Einar K. Rofstad and T. Brustad},
  journal={The British journal of radiology},
  year={1978},
  volume={51 605},
  pages={381-6}
}
The radiosensitizing effect of two electron-affinic nitroimidazoles, metronidazole and misonidazole (Ro-07-0582), has been tested on a human malignant melanoma grown subcutaneously in the athymic mutant nude mouse. A 60Co therapy unit was used for local irradiation of the mice. Metronidazole in doses of 750 mg/kg and misonidazole in doses of 500 mg/kg were… CONTINUE READING