The radiosensitization effect of parthenolide in prostate cancer cells is mediated by nuclear factor-kappaB inhibition and enhanced by the presence of PTEN.

@article{Sun2007TheRE,
  title={The radiosensitization effect of parthenolide in prostate cancer cells is mediated by nuclear factor-kappaB inhibition and enhanced by the presence of PTEN.},
  author={Yulan Sun and Daret K. St. Clair and Fang Fang and Graham Walter Warren and Vivek M. Rangnekar and Peter A. Crooks and William H. St. Clair},
  journal={Molecular cancer therapeutics},
  year={2007},
  volume={6 9},
  pages={2477-86}
}
Parthenolide has been shown to have anti-inflammatory and antitumor properties. However, whether and how parthenolide enhances tumor sensitivity to radiation therapy are unknown. In this study, we show that inhibition of the nuclear factor-kappaB (NF-kappaB) pathway is a common mechanism for the radiosensitization effect of parthenolide in prostate cancer cells LNCaP, DU 145, and PC3. Parthenolide inhibits radiation-induced NF-kappaB DNA-binding activity and the expression of its downstream… CONTINUE READING

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