The radiosensitivity of the human oocyte.

@article{Wallace2003TheRO,
  title={The radiosensitivity of the human oocyte.},
  author={W. Hamish B. Wallace and Angela B Thomson and Thomas W. Kelsey},
  journal={Human reproduction},
  year={2003},
  volume={18 1},
  pages={117-21}
}
BACKGROUND We determined the best model available for natural follicle decline in healthy women and used this to calculate the radiosensitivity of the human oocyte. METHODS Ovarian failure was diagnosed in six patients with a median age of 13.2 years (range 12.5-16.0) who were treated with total body irradiation (14.4 Gy) at 11.5 years of age (4.9-15.1). We previously estimated the dose of radiation required to destroy 50% of the oocytes (LD(50)) to be <4 Gy. This estimate is an… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 142 extracted citations

Etiology and treatment of hypogonadism in adolescents.

Pediatric clinics of North America • 2011
View 3 Excerpts
Highly Influenced

Female fertility and colorectal cancer

International Journal of Colorectal Disease • 2008
View 4 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 20 references

A Quantitative and Cytological Study of Germ Cells in Human Ovaries.

Proceedings of the Royal Society of London. Series B, Biological sciences • 1963
View 7 Excerpts
Highly Influenced

CaracteÂres qualitatifs et quantitatifs de la population ®lliculaire dans l'ovaire humain adulte

A. Gougeon
Contracep. Fertil. Sex., • 1984
View 3 Excerpts
Highly Influenced

Cytotoxic insult to germinal tissue, part 2; The ovary

M. Bianchi
1983
View 3 Excerpts
Highly Influenced

Menstrual cyclicity and the pre-menopause.

Maturitas • 1981
View 2 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…