The radiosensitivity of 5- and 6-bromocytidine derivatives--electron induced DNA degradation.

@article{Chomicz2014TheRO,
  title={The radiosensitivity of 5- and 6-bromocytidine derivatives--electron induced DNA degradation.},
  author={Lidia Chomicz and Łukasz Golon and Janusz Rak},
  journal={Physical chemistry chemical physics : PCCP},
  year={2014},
  volume={16 36},
  pages={
          19424-8
        }
}
Halogenated nucleotides belong to the group of radiosensitizers that sensitize solid tumors when incorporated into genomic DNA. Here, we consider the propensity of two isomeric bromocytidine derivatives, 3',5'-diphosphates of 5-bromo-2'-deoxycytidine (5BrdCDP) and 6-bromo-2'-deoxycytidine (6BrdCDP), to be damaged by electrons - one of the most abundant products formed during radiotherapy. An intranucleotide degradation mechanism leading to phosphodiester bond breakage (a model of single strand… CONTINUE READING

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