The radical scavenger edaravone prevents oxidative neurotoxicity induced by peroxynitrite and activated microglia

@article{Banno2005TheRS,
  title={The radical scavenger edaravone prevents oxidative neurotoxicity induced by peroxynitrite and activated microglia},
  author={Masahiro Banno and Tetsuya Mizuno and Hideki Kato and Guiqin Zhang and Jun Kawanokuchi and Jinyan Wang and Reiko Kuno and Shijie Jin and Hideyuki Takeuchi and Akio Suzumura},
  journal={Neuropharmacology},
  year={2005},
  volume={48},
  pages={283-290}
}
The free radical scavenger edaravone has been used as an anti-oxidative agent in acute ischemic brain disorders. We examined the effect of edaravone on the production of nitric oxide (NO), reactive oxygen species (ROS) and proinflammatory cytokines by activated microglia, and we also examined its neuroprotective role in cortical neuronal cultures oxidatively stressed by the peroxynitrite donor N-morpholinosydnonimine (SIN-1) or activated microglia. Edaravone significantly suppressed the… Expand
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