The radiation-induced cell-death signaling pathway is activated by concurrent use of cisplatin in sequential biopsy specimens from patients with cervical cancer.

Abstract

OBJECTIVE To identify changes in gene expression related to the concurrent use of platinum compounds with radiotherapy, in the treatment of cervical cancer. PATIENTS AND METHODS Biopsy specimens were obtained from 39 patients with squamous cell carcinoma of the uterine cervix, before and during fractionated radiotherapy. Twenty patients were treated with… (More)

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@article{Iwakawa2007TheRC, title={The radiation-induced cell-death signaling pathway is activated by concurrent use of cisplatin in sequential biopsy specimens from patients with cervical cancer.}, author={Mayumi Iwakawa and Tatsuya Ohno and Kaori Imadome and Miyako Nakawatari and Ken-Ichi Ishikawa and Minako Sakai and Shingo Katoh and Hitoshi Ishikawa and Hirohiko Tsujii and Takashi Imai}, journal={Cancer biology & therapy}, year={2007}, volume={6 6}, pages={905-11} }