The rad18 gene of Schizosaccharomyces pombe defines a new subgroup of the SMC superfamily involved in DNA repair.

@article{Lehmann1995TheRG,
  title={The rad18 gene of Schizosaccharomyces pombe defines a new subgroup of the SMC superfamily involved in DNA repair.},
  author={A. R. Lehmann and M Walicka and David J Griffiths and J. M. Murray and Felicity Z. Watts and Shirley McCready and Antony M Carr},
  journal={Molecular and cellular biology},
  year={1995},
  volume={15 12},
  pages={7067-80}
}
The rad18 mutant of Schizosaccharomyces pombe is very sensitive to killing by both UV and gamma radiation. We have cloned and sequenced the rad18 gene and isolated and sequenced its homolog from Saccharomyces cerevisiae, designated RHC18. The predicted Rad18 protein has all the structural properties characteristic of the SMC family of proteins, suggesting a motor function--the first implicated in DNA repair. Gene deletion shows that both rad18 and RHC18 are essential for proliferation. Genetic… CONTINUE READING

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Cloning and characterisation of the Schizosaccharomyces pombe rad32 gene: a gene required for repair of double strand breaks and recombination

  • M. Tavassoli, M. Shayegi, A. Nasim, F. Z. Watts
  • Nucleic Acids Res
  • 1995

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