33 Citations
An update of anti-viral treatment of COVID-19
- Medicine, BiologyTurkish Journal of Medical Sciences
- 2021
Monoclonal antibodies seem to be the most effective treatment for COVID-19 at the moment, and high-titer convalescent plasma also could be effective when administered during the early phase of the disease.
Untapping host-targeting cross-protective efficacy of anticoagulants against SARS-CoV-2
- BiologyPharmacology & Therapeutics
- 2021
Broad spectrum antiviral nucleosides—Our best hope for the future
- BiologyAnnual Reports in Medicinal Chemistry
- 2021
Doxycycline Inhibition of a Pseudotyped Virus Transduction Does Not Translate to Inhibition of SARS-CoV-2 Infectivity
- BiologyViruses
- 2021
Doxycycline inhibited the transduction of the pseudotyped virus in Vero E6 and HEK-293 T cells stably expressing human receptor angiotensin-converting enzyme 2 but did not affect the entry and replication of SARS-CoV-2.
Doxycycline inhibition of a pseudotyped virus transduction does not translate to inhibition of SARS-CoV-2 infectivity
- BiologybioRxiv
- 2021
Doxycycline inhibited the transduction of the pseudotyped virus in Vero E6 and HEK-293 T cells stably expressing human receptor angiotensin-converting enzyme 2 but did not affect the entry and replication of SARS-CoV-2.
Efficacy of repurposed antiviral drugs: Lessons from COVID-19
- Biology, MedicineDrug Discovery Today
- 2022
Efficacy of repurposed antiviral drugs: lessons from COVID-19
- Biology, MedicineDrug Discovery Today
- 2022
Enabling evidence to tackle everyday diseases to mitigate another pandemic
- MedicineGates Open Research
- 2022
The next emergent novel pathogen is likely to occur where the ability to undertake health research and collect life-saving data is lacking, thereby enabling undetected infection and unchecked transmission within a community.
Insights Into Drug Repurposing, as Well as Specificity and Compound Properties of Piperidine-Based SARS-CoV-2 PLpro Inhibitors
- Biology, ChemistryFrontiers in Chemistry
- 2022
This work reports an effort to identify PLpro inhibitors by screening the ReFRAME library of 11,804 compounds, showing that none inhibit PLpro with any reasonable activity or specificity, and arrives at compounds with improved and favorable solubility and stability characteristics that are tested for inhibiting viral replication.
Insights into the binding and covalent inhibition mechanism of PF-07321332 to SARS-CoV-2 Mpro
- Chemistry, BiologyRSC advances
- 2022
It is found that the catalytic triad Cys145–His41–Asp187 of SARS-CoV-2 Mpro plays an important role in the activation of the PF-07321332 covalent inhibitor, which renders the deprotonation of Cys 145 and, thus, facilitates further reaction.
References
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An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice
- Biology, ChemistryScience Translational Medicine
- 2020
A ribonucleoside analog inhibits SARS-CoV-2 in human airway epithelial cell cultures and SARS-CoV and MERS-CoV in mice. Catastrophic consequences Broad-spectrum antivirals are desirable, particularly…
Discovery of Ketone-Based Covalent Inhibitors of Coronavirus 3CL Proteases for the Potential Therapeutic Treatment of COVID-19
- Biology, ChemistryJournal of medicinal chemistry
- 2020
Preclinical experiments reveal 4 (PF-00835231) as a potent inhibitor of CoV-2 3CLpro with suitable pharmaceutical properties to warrant further development as an intravenous treatment for COVID-19.
Remdesivir for the Treatment of Covid-19 — Final Report
- MedicineThe New England journal of medicine
- 2020
The data show that remdesivir was superior to placebo in shortening the time to recovery in adults who were hospitalized with Covid-19 and had evidence of lower respiratory tract infection.
Repurposed Antiviral Drugs for Covid-19 — Interim WHO Solidarity Trial Results
- MedicineThe New England journal of medicine
- 2020
These remdesivir, hydroxychloroquine, lopinavir, and interferon regimens had little or no effect on hospitalized patients with Covid-19, as indicated by overall mortality, initiation of ventilation, and duration of hospital stay.
Therapeutic treatment of Zika virus infection using a brain-penetrating antiviral peptide
- Biology, MedicineNature Materials
- 2018
An amphiphatic peptide is now shown to penetrate the blood–brain barrier, reducing viral loads due to its activity against Zika and other mosquito-borne viruses.
Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses
- Biology, MedicineScience Translational Medicine
- 2017
Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses in vitro and in vivo and may prove effective against endemic MERS-CoV in the Middle East, circulating human CoV, and, possibly most importantly, emerging CoV of the future.