The race for antiviral drugs to beat COVID - and the next pandemic.

@article{Dolgin2021TheRF,
  title={The race for antiviral drugs to beat COVID - and the next pandemic.},
  author={Elie S Dolgin},
  journal={Nature},
  year={2021},
  volume={592 7854},
  pages={
          340-343
        }
}
  • E. Dolgin
  • Published 1 April 2021
  • Medicine
  • Nature
View on PubMed
doi.org
33 Citations
Highly Influential Citations
5
Background Citations
14
Methods Citations
1

33 Citations

Citation Type

Citation Type

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Monoclonal antibodies seem to be the most effective treatment for COVID-19 at the moment, and high-titer convalescent plasma also could be effective when administered during the early phase of the disease.
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Doxycycline Inhibition of a Pseudotyped Virus Transduction Does Not Translate to Inhibition of SARS-CoV-2 Infectivity
TLDR
Doxycycline inhibited the transduction of the pseudotyped virus in Vero E6 and HEK-293 T cells stably expressing human receptor angiotensin-converting enzyme 2 but did not affect the entry and replication of SARS-CoV-2.
Doxycycline inhibition of a pseudotyped virus transduction does not translate to inhibition of SARS-CoV-2 infectivity
TLDR
Doxycycline inhibited the transduction of the pseudotyped virus in Vero E6 and HEK-293 T cells stably expressing human receptor angiotensin-converting enzyme 2 but did not affect the entry and replication of SARS-CoV-2.
Efficacy of repurposed antiviral drugs: Lessons from COVID-19
Efficacy of repurposed antiviral drugs: lessons from COVID-19
Enabling evidence to tackle everyday diseases to mitigate another pandemic
  • T. Lang
  • Medicine
    Gates Open Research
  • 2022
TLDR
The next emergent novel pathogen is likely to occur where the ability to undertake health research and collect life-saving data is lacking, thereby enabling undetected infection and unchecked transmission within a community.
Insights Into Drug Repurposing, as Well as Specificity and Compound Properties of Piperidine-Based SARS-CoV-2 PLpro Inhibitors
TLDR
This work reports an effort to identify PLpro inhibitors by screening the ReFRAME library of 11,804 compounds, showing that none inhibit PLpro with any reasonable activity or specificity, and arrives at compounds with improved and favorable solubility and stability characteristics that are tested for inhibiting viral replication.
Insights into the binding and covalent inhibition mechanism of PF-07321332 to SARS-CoV-2 Mpro
TLDR
It is found that the catalytic triad Cys145–His41–Asp187 of SARS-CoV-2 Mpro plays an important role in the activation of the PF-07321332 covalent inhibitor, which renders the deprotonation of Cys 145 and, thus, facilitates further reaction.
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