The race for antiviral drugs to beat COVID - and the next pandemic.

@article{Dolgin2021TheRF,
  title={The race for antiviral drugs to beat COVID - and the next pandemic.},
  author={Elie S Dolgin},
  journal={Nature},
  year={2021},
  volume={592 7854},
  pages={
          340-343
        }
}
  • E. Dolgin
  • Published 1 April 2021
  • Medicine
  • Nature
View on PubMed
doi.org
21 Citations
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21 Citations

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This review systemically summarized the recent applications of nanoagents in diagnostics and therapeutics for HCoV-induced diseases, as well as their limitations and perspectives against H coV variants, and believes this review will promote the design of innovative theranostic nanoagents for the current and future H CoV-caused pandemics.
Anno 2021: Which antivirals for the coming decade?
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The recent progress that has been made in the search for new antivirals against these different threats that the world population will need to confront with increasing frequency in the next decade are summarized.
Antiviral Activity of Influenza A Virus Defective Interfering Particles against SARS-CoV-2 Replication In Vitro through Stimulation of Innate Immunity
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IAV DIPs are proposed as an effective antiviral agent for treatment of COVID-19, and potentially also for suppressing the replication of new variants of SARS-CoV-2.
Antivirals for Coexistence with COVID-19: Brief Review for General Physicians
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Although the severe acute respiratory syndrome coronavirus 2 will not be completely eradicated, if the use of antiviral drugs is established, the COVID-19 pandemic will end through coexistence with the virus.
Biophysical Measurement Strategies for Antiviral Drug Development: Recent Progress in Virus-Mimetic Platforms Down to the Single Particle Level.
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This Account summarizes biophysical measurements that the group has successfully adopted to develop broad-spectrum antiviral drugs based on the lipid envelope antiviral disruption (LEAD) strategy, targeting the structural integrity of the outer viral membrane to abrogate viral infectivity.
Bispecific repurposed medicines targeting the viral and immunological arms of COVID-19
TLDR
Two non-antiviral therapeutic agents are described, the caspase-1 inhibitor SDZ 224015 and Tarloxotinib that target Mpro and PLpro, respectively that have both undergone safety evaluation in humans and hence are candidates for COVID-19 clinical evaluation.
Broad spectrum antiviral nucleosides—Our best hope for the future
TLDR
A brief summary of prominent nucleoside analogues that previously exhibited broad-spectrum activity and are now under renewed interest, as well as new analogues, that are currently under investigation against SARS-CoV-2 and other viruses is discussed herein.
Chemoinformatics and Machine Learning Approaches for Identifying Antiviral Compounds.
TLDR
The study demonstrated scaffold analysis of the molecules as a pragmatic approach to explore the importance of structurally diverse compounds in data driven studies and developed Machine Learning based predictive models that can be used to assess whether a compound has the potency to be antiviral or not.
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