The rabbit pulmonary monooxygenase system. Immunochemical and biochemical characterization of enzyme components.

@article{SerabjitSingh1979TheRP,
  title={The rabbit pulmonary monooxygenase system. Immunochemical and biochemical characterization of enzyme components.},
  author={Cosette J. Serabjit-Singh and C. R. Wolf and Richard M. Philpot},
  journal={The Journal of biological chemistry},
  year={1979},
  volume={254 19},
  pages={
          9901-7
        }
}
The enzymatic components of the rabbit pulmonary monooxygenase system, cytochromes P-450I and P-450II and NADPH-cytochrome P-450 reductase, are immunochemically distinct proteins. In pulmonary microsomes, the N-demethylation of benzphetamine, amino-pyrine, and ethylmorphine, and the O-deethylation of 7-ethoxycoumarin are dependent only on cytochrome P-450I, and the hydroxylation of coumarin is apparently catalyzed by both cytochromes. Cytochrome P-450II is immunochemically distinct from the… CONTINUE READING
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