The rRNA-processing function of the yeast U14 small nucleolar RNA can be rescued by a conserved RNA helicase-like protein.

@article{Liang1997TheRF,
  title={The rRNA-processing function of the yeast U14 small nucleolar RNA can be rescued by a conserved RNA helicase-like protein.},
  author={Wenjie Liang and Julia A. Clark and Maurille J. Fournier},
  journal={Molecular and cellular biology},
  year={1997},
  volume={17 7},
  pages={
          4124-32
        }
}
The phylogenetically conserved U14 small nucleolar RNA is required for processing of rRNA, and this function involves base pairing with conserved complementary sequences in 18S RNA. With a view to identifying other important U14 interactions, a stem-loop domain required for activity of Saccharomyces cerevisiae U14 RNAs (the Y domain) was first subjected to detailed mutational analysis. The mapping results showed that most nucleotides of the Y domain can be replaced without affecting function… CONTINUE READING

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  • 2011
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