The quest for exceptional drug solubilization in diluted surfactant solutions and consideration of residual solid state

@article{Saal2018TheQF,
  title={The quest for exceptional drug solubilization in diluted surfactant solutions and consideration of residual solid state},
  author={Wiebke Saal and Nicole Wyttenbach and Jochem Alsenz and Martin Kuentz},
  journal={European Journal of Pharmaceutical Sciences},
  year={2018},
  volume={111},
  pages={96–103}
}
View on Wolters Kluwer
ncbi.nlm.nih.gov
5 Citations
Background Citations
1

Figures and Tables from this paper

5 Citations

Predictive Modeling of Micellar Solubilization by Single and Mixed Nonionic Surfactants.
Hydroxypropyl methylcellulose acetate succinate as an exceptional polymer for amorphous solid dispersion formulations: A review from bench to clinic.
  • Arun Butreddy
  • Materials Science
    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
  • 2022
Self-Assembling Drug Formulations with Tunable Permeability and Biodegradability
TLDR
Nonionic surfactants are primarily discussed, including their application for the fabrication of nanocarriers, their surfactant-skin interactions, the mechanisms of modulating their permeability, and the factors controlling drug encapsulation, release, and targeted delivery.
Synergistic Computational Modeling Approaches as Team Players in the Game of Solubility Predictions.
Approaches to increase mechanistic understanding and aid in the selection of precipitation inhibitors for supersaturating formulations – a PEARRL review
TLDR
This review will focus on recent advances that utilise advanced analytical techniques to increase mechanistic understanding of PI action and systematic PI selection.

References

SHOWING 1-10 OF 37 REFERENCES
Effect of surfactant mixing on partitioning of model hydrophobic drug, naproxen, between aqueous and micellar phases.
TLDR
Use of RSA has been extended, with fair success, to predict the partition coefficient of ternary surfactant systems using data from binary mixtures, and theoretical micelle-water partition coefficients calculated from the geometric mean equation compared well with experimental values.
Miniaturized X-ray powder diffraction assay (MixRay) for quantitative kinetic analysis of solvent-mediated phase transformations in pharmaceutics.
Biopharmaceutical classification of poorly soluble drugs with respect to "enabling formulations".
Miniaturized Assay for Solubility and Residual Solid Screening (SORESOS) in Early Drug Development
TLDR
The new assay allows the simultaneous, small scale screening of drug solubility in various pharmaceutical vehicles and identification of changes in solid form and is useful for the identification of formulations and formulation options in non-clinical and clinical development.
Micellization phenomena of amphiphilic drug and TX-100 mixtures: Fluorescence, UV-visible and 1H NMR study
Surfactant-facilitated crystallization of dihydrate carbamazepine during dissolution of anhydrous polymorph.
TLDR
The influence of two structurally different anionic surfactants on the anhydrous-to-dihydrate transformation of carbamazepine was investigated and it was shown that both surfactant promoted the crystallization of CBZ dihydrate during dissolution of the anHydrous monoclinic polymorph.
Solubilization in Surfactant Aggregates
Part 1 Overview: overview and history of the study of solubilization. Part 2 Solubilization in micelles: solubilization of gases thermodynamics of solubilization of polar additives in micellar…
Solvent-mediated solid phase transformations of carbamazepine: Effects of simulated intestinal fluid and fasted state simulated intestinal fluid.
TLDR
The results underline the importance of biologically representative dissolution media in linking the in vitro dissolution results of solids that are capable of hydrate formation to their in vivo dissolution behavior.
50years of oral lipid-based formulations: Provenance, progress and future perspectives.
Computational Prediction of Drug Solubility in Lipid Based Formulation Excipients
TLDR
Solubility measured in one excipient can be used to predict solubility in another, herein exemplified with TGMCversus TGLC, and PS80 versus PEG400, and it is shown, for the first time, that solubilty in TGMC and TGLC can be predicted from rapidly calculated molecular descriptors.
...
...