The quest for an image of brain

  title={The quest for an image of brain},
  author={William H. Oldendorf},
  pages={517 - 517}
Each of the brain imaging techniques in common clinical use (skull radiography, midline ultrasonography, isotope scan, pneumoencephalography, angiography and computerized tomography) depicts some structural or functional characteristic of the brain. Each produces a correspondingly restricted concept of the status of the brain. Computerized tomography, which defines the radiodensity of head tissues, has a fundamental advantage over the other techniques in that it defines with quite good… 

The First CT Scan of the Brain: Entering the Neurologic Information Age

This historical vignette discusses the development of CT scanning of the brain and its connection with neurocritical care.

Magnetic resonance imaging in the evaluation of cognitive function

  • E. Bigler
  • Medicine, Psychology
    Pediatric blood & cancer
  • 2014
The current presentation overviews the current status of MRI methods for routine clinical assessment of brain pathology, how these techniques identify neuropathology and how pathological findings are quantified, and howThese techniques permit an examination of brain function and connectivity.

Neuroradiology Back to the Future: Brain Imaging

The origin and evolution of the advances that have led to the quicker, less invasive diagnosis and resulted in more rapid therapy and improved outcomes are traced.


  • Medicine
Physicians should understand the appropriate utilization of these neuroimaging studies and order these studies only when they are of clinical value and not utilize these studies when there are no clinical indications to support their utilization.

Incidental focal intracranial computed tomographic findings.

  • L. Weisberg
  • Medicine
    Journal of neurology, neurosurgery, and psychiatry
  • 1982
Of 3000 consecutive computed tomography (CT) head scans there were 28 adult patients who had a focal intracranial lesion, who presented with nonspecific symptoms, and who had normal initial

Computed cranial tomography in children.

  • P. Ferry
  • Medicine
    The Journal of pediatrics
  • 1980

Neuropsychological Assessment and Rehabilitation

The role of clinical neuropsychological assessment in rehabilitation settings is not a novel concept but the need for localization of brain lesions with neuropsychologic techniques virtually ceased to be an issue with the introduction of computerized tomographic and position emission transaxial tomographic scans in the middle 1970s.

Computed tomography in the diagnosis of intracranial disease.

Computed tomography may detect and define the underlying pathologic processes more directly than is possible with other diagnostic procedures and has reduced the need for invasive contrast procedures.

Computed tomographic brain scanning in children with developmental neuropsychiatric disorders.



Scanning of Positron-Emitting Isotopes in Diagnosis of Intracranial and other Lesions

In the laboratory the normal intracellular ions, phosphate and potassium, have been found to concentrate to a greater degree in human brain tumor relative to normal brain than any other substances.

The Mark IV system for radionuclide computed tomography of the brain.

The Mark IV scanning system is a simple four-sided arrangement of 32 independent detectors which rotate continously as a unit, detecting, processing, and displaying the reconstructed data while the study progresses, with good reproducibility and accuracy for absolute quantification of radionuclide concentration in the brain.

Basic principles of computed axial tomography.


THE value of rontgenography in the diagnosis and localization of intracranial tumors is mainly restricted to the cases in which the neoplasm has affected the skull. In an analysis of the X-ray

Distribution of various classes of radiolabeled tracers in plasma, scalp, and brain.

  • W. Oldendorf
  • Biology, Medicine
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine
  • 1972
Basic studies of tissue distribution in animals were undertaken to aid in under standing radionuclide distributions in the human head during clinical studies.

Theory of image reconstruction in computed tomography.

Mathematical methods are of central importance in the new technologies of radiographic and radioisotopic image reconstruction. The most important procedures are classified as Back-projection,

Changes in size of normal lateral ventricles during aging determined by computerized tomography

The range of normal ventricular size was relatively more wide in the eighth and ninth decades than in the first seven; thus, abnormalities of ventricularSize may be more easily identified in younger than older subjects.

Attenuation coefficients of various body tissues, fluids, and lesions at photon energies of 18 to 136 keV.

Radioactive sources of 241Am, 125I, 153Gd, 170Tm, and 57Co were used to measure the attenuation coefficient muL of various body tissues, fluids, and cerebral lesions to provide a better understanding of the photon interactions at the sensitivity level of computed tomography.

Computed tomograpy and neuroradiology: a fortunate primary union.

  • H. Baker
  • Medicine
    AJR. American journal of roentgenology
  • 1976
Computed tomography has led to extensive reassessment of and alterations in the practices of neuroscientists and the principles evolving should apply in many situations as the benefits of CT are extended to other portions of the body.


  • E. Davis
  • Medicine
    Proceedings of the Australian Association of Neurologists
  • 1966
Before embarking on neuro-radlological studies, it is advantageous to have diagnostic routine examinations which are without risk, which may be repeated any number of times, and which may ensure a reliable primary diagnosis.