The quantitative trait gene latexin influences the size of the hematopoietic stem cell population in mice

@article{Liang2007TheQT,
  title={The quantitative trait gene latexin influences the size of the hematopoietic stem cell population in mice},
  author={Ying Liang and Michael Jansen and Bruce J. Aronow and Hartmut Geiger and Gary Van Zant},
  journal={Nature Genetics},
  year={2007},
  volume={39},
  pages={178-188}
}
We mapped quantitative trait loci that accounted for the variation in hematopoietic stem cell (HSC) numbers between young adult C57BL/6 (B6) and DBA/2 (D2) mice. In reciprocal chromosome 3 congenic mice, introgressed D2 alleles increased HSC numbers owing to enhanced proliferation and self-renewal and reduced apoptosis, whereas B6 alleles had the opposite effects. Using oligonucleotide arrays, real-time PCR and protein blots, we identified latexin (Lxn), a gene whose differential transcription… CONTINUE READING
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