The quantitative association of plasma endotoxin, antithrombin, protein C, extrinsic pathway inhibitor and fibrinopeptide A in systemic meningococcal disease.

@article{Brandtzaeg1989TheQA,
  title={The quantitative association of plasma endotoxin, antithrombin, protein C, extrinsic pathway inhibitor and fibrinopeptide A in systemic meningococcal disease.},
  author={P E R Brandtzaeg and Per M Sandset and Gun Britt Jo\o and Reidun Ovsteb\o and Ulrich Abildgaard and Peter B Kierulf},
  journal={Thrombosis research},
  year={1989},
  volume={55 4},
  pages={459-70}
}
We have evaluated the quantitative relationship between lipopolysaccharide (LPS, endotoxin), fibrinopeptide A (FPA), antithrombin (AT), protein C (PC) and extrinsic pathway inhibitor (EPI) in plasma from 39 consecutively admitted patients with systemic meningococcal disease (SMD). The most severely ill patients with fulminant meningococcal septicemia (n = 13, 6 dead) had significantly (p less than 0.01) higher plasma levels of LPS and FPA and lower levels of PC and AT on admission as compared… CONTINUE READING