The quantitative analysis of peripheral blood FOXP3-expressing T cells in systemic lupus erythematosus and rheumatoid arthritis patients.

@article{Lin2007TheQA,
  title={The quantitative analysis of peripheral blood FOXP3-expressing T cells in systemic lupus erythematosus and rheumatoid arthritis patients.},
  author={Shih-Chang Lin and K-H Chen and Chung-Hui Lin and C-C Kuo and Q A Ling and C-H Chan},
  journal={European journal of clinical investigation},
  year={2007},
  volume={37 12},
  pages={987-96}
}
BACKGROUND Expressed in naturally occurring CD4+CD25+ regulatory T cells, FoxP3 plays an important role in maintaining immune tolerance. We therefore evaluated the possibility that the peripheral blood FOXP3+ T-cell deficiency is associated with systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). MATERIALS AND METHODS The FOXP3 expression in peripheral blood T cells were evaluated and correlated to the CD4 and CD25 expression by flow cytometric analysis. Cell frequencies of… CONTINUE READING