The qualitative nature of the primary immune response to HIV infection is a prognosticator of disease progression independent of the initial level of plasma viremia.

@article{Pantaleo1997TheQN,
  title={The qualitative nature of the primary immune response to HIV infection is a prognosticator of disease progression independent of the initial level of plasma viremia.},
  author={Giuseppe Pantaleo and James F. Demarest and Timothy W Schacker and Mauro Vaccarezza and Oren Cohen and Marybeth Daucher and Cecilia Graziosi and Steven Schnittman and Thomas C Quinn and George M. Shaw and Luc Perrin and Giuseppe Tambussi and Adriano Lazzarin and Rafick Pierre S{\'e}kaly and Hugo Soudeyns and Lawrence Corey and Anthony S. Fauci},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1997},
  volume={94 1},
  pages={254-8}
}
Following infection of the host with a virus, the delicate balance between virus replication/spread and the immune response to the virus determines the outcome of infection, i.e., persistence versus elimination of the virus. It is unclear, however, what relative roles immunologic and virologic factors play during primary viral infection in determining the subsequent clinical outcome. By studying a cohort of subjects with primary HIV infection, it has been demonstrated that qualitative… CONTINUE READING

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