The quaking mouse: an epileptic mutant with alterations affecting the modulatory mechanisms of the NMDA receptor complex

@article{Mitrovic1991TheQM,
  title={The quaking mouse: an epileptic mutant with alterations affecting the modulatory mechanisms of the NMDA receptor complex},
  author={Nadia Mitrovic and Jocelyne Caboche and Jacques Carr{\'e} and Mapsych. Jacques Besson and Yves Maurin},
  journal={Brain Research},
  year={1991},
  volume={566},
  pages={248-254}
}
The binding of [3H]glutamate and of [3H]1-(1-(2-thienyl)cyclohexyl)piperidine [( 3H]TCP) has been examined in the genetically epileptic mutant mouse, quaking. The density of [3H]glutamate binding sites did not differ between the quaking mice and their controls of the same strain. In the absence of exogenous glutamate or glycine, the density of [3H]TCP binding sites was also similar in the two strains. In both the mutants and their controls, exogenously added glutamate, glycine and glutamate… CONTINUE READING
BETA