The pyruvate dehydrogenase complex is partially inactivated during early recirculation following short-term forebrain ischemia in rats.

@article{Zaidan1998ThePD,
  title={The pyruvate dehydrogenase complex is partially inactivated during early recirculation following short-term forebrain ischemia in rats.},
  author={Emad Zaidan and K F Sheu and Neil Sims},
  journal={Journal of neurochemistry},
  year={1998},
  volume={70 1},
  pages={233-41}
}
The mechanisms of selective neuronal loss after short-term global ischemia remain undefined, but processes including increased proteolytic activity, impaired protein synthesis, and oxidative damage have been proposed to contribute. A decrease in activity of the pyruvate dehydrogenase complex in the dorsolateral striatum, an ischemia-susceptible region, is one change apparently differentiating this region from ischemia-resistant areas during early recirculation. To provide an insight into… CONTINUE READING

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