The pyrrole moiety as a template for COX-1/COX-2 inhibitors.

  title={The pyrrole moiety as a template for COX-1/COX-2 inhibitors.},
  author={Gerd Dannhardt and Werner Kiefer and G{\"u}nter Kr{\"a}mer and S Maehrlein and Ulrike Nowe and Bernd L. Fiebich},
  journal={European journal of medicinal chemistry},
  volume={35 5},
Aroyl- and thiophene-substituted pyrrole derivatives have been synthesized as a new class of COX-1/COX-2 inhibitors. The inhibition of COX-1 was evaluated in a biological system using bovine PMNLs as the enzyme source, whereas LPS-stimulated human monocytes served as the enzyme source for inducible COX-2. The determination of the concentration of arachidonic acid metabolites was performed by HPLC for COX-1 and RIA for COX-2. Variation of the substitution pattern led to a series of active… CONTINUE READING
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