The pyrogenicity of the synthetic adjuvant muramyl dipeptide and two structural analogues.

@article{Dinarello1978ThePO,
  title={The pyrogenicity of the synthetic adjuvant muramyl dipeptide and two structural analogues.},
  author={Charles Anthony Dinarello and Ronald J. Elin and Louis Chedid and Sheldon M. Wolff},
  journal={The Journal of infectious diseases},
  year={1978},
  volume={138 6},
  pages={760-7}
}
The pyrogenic efect of the synthetic adjuvant N-acetylmuramyl-L-alanine-D-isoglutamine, also known as muramyl dipeptide (MDP), was studied in rabbits. MDP induced biphasic fevers in rabbits, but two structural analogues, N-acetylmuramyl-L-alanine-D-glutamic acid (MDPA) and the dimethylester of MDPA, were 10 times less pyrogenic. This finding was supported by studies in which MDP and its analogues released leukocytic pyrogen (LP) from rabbit phagocytic cells in vitro. In addition, MDP released… CONTINUE READING