The pyridinylfuranopyrimidine inhibitor, PI-103, chemosensitizes glioblastoma cells for apoptosis by inhibiting DNA repair

@article{Westhoff2009ThePI,
  title={The pyridinylfuranopyrimidine inhibitor, PI-103, chemosensitizes glioblastoma cells for apoptosis by inhibiting DNA repair},
  author={Mike-Andrew Westhoff and Julia Annabel Kandenwein and Sabine Karl and Sri Hari Krishna Vellanki and Veit Braun and Adriana Eramo and G. Antoniadis and K -M Debatin and Simone Fulda},
  journal={Oncogene},
  year={2009},
  volume={28},
  pages={3586-3596}
}
The failure of conventional therapies in glioblastoma (GBM) is largely due to an aberrant activity of survival cascades, such as PI3 kinase (PI3K)/Akt-mediated signaling. This study is the first to show that the class I PI3K inhibitor, PI-103, enhances chemotherapy-induced cell death of GBM cells. Concurrent treatment with PI-103 and DNA-damaging drugs, in… CONTINUE READING