The pyrethroids permethrin and cyhalothrin are potent inhibitors of the mitochondrial complex I.

Abstract

The synthetic pyrethroid derivatives permethrin and cyhalothrin are widely used insecticides that are considered to be relatively nontoxic to higher animals. However, a variety of toxic effects on mammals have been reported. We investigated the effect of these drugs on energy coupling by mitochondria and on the activity of the individual respiratory… (More)

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