The puzzling role of TRAIL in endothelial cell biology.

  title={The puzzling role of TRAIL in endothelial cell biology.},
  author={Paola Secchiero and Giorgio Zauli},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  volume={28 2},
  pages={e4; author reply e5-6}
Cell Biology To the Editor: In their study published online in Arteriosclerosis, Thrombosis, and Vascular Biology, O’Brien et al demonstrate that activated protein C (APC) decreases tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) expression in endothelial cells.1 Although the molecular mechanism by which APC decreases the expression of TRAIL mRNA and protein via an Egr-1/Erk-1/2 pathway appears convincing, much less clear is whether the downregulation of TRAIL reflects a… CONTINUE READING