The puzzle of HIV‐1 subtypes in Africa

  title={The puzzle of HIV‐1 subtypes in Africa},
  author={Wouter Janssens and Anne Buvé and John N. Nkengasong},
HIV has a high degree of genetic variability. While much is known about the differences between HIV-1 and HIV-2 in terms of transmissibility pathogenesis and pattern of spread much remains to be learned about the biological characteristics and epidemic spread of the different HIV-1 strains. Before 1992 HIV-1 strains were classified on the basis of their geographic origin into North American and African variants. However since 1992 the env coding sequence has been used to classify globally… 
Significance of HIV-1 Genetic Subtypes
  • A. Alaeus
  • Biology
    Scandinavian journal of infectious diseases
  • 2000
HIV is the most significant new pathogen that emerged during the twentieth century. Since the recognition of AIDS in 1981, HIV has caused a worldwide epidemic. HIV-1 mutates extensively and shows
Evolution and Diversity of HIV-1 in Africa – a Review
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Human immunodeficiency virus type 1 subtypes differ in disease progression.
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High diversity of HIV-1 subtype F strains in Central Africa.
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Molecular analysis and phylogenetic characterization of HIV in Iran
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Subtype C is the predominant HIV-1 subtype in Gauteng associated with heterosexual transmission and it is likely that future vaccine strategies will be directed towards this subtype.
Interaction with human immunodeficiency virus (HIV) type 2 predicts HIV type 1 genotype.
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HIV-1 patients may harbor viruses of different phylogenetic subtypes: implications for the evolution of the HIV/AIDS pandemic.
A genetic method based on restriction site polymorphism to screen for homotypic HIV1 mixed infections within infected populations, and certain restriction enzymes may be used to predict the phylogroup of HIV-1 infected samples.
A highly heterogeneous HIV-1 epidemic in the Central African Republic.
Findings on the distribution of HIV-1 infections and serologic reactivities of HIV in the Central African Republic are presented.
Epidemiology and transmission of HIV-2. Why there is no HIV-2 pandemic.
Differences in viral load throughout most of the natural history of infection appear to correlate with lower transmissibility of HIV-2 than HIV-1, and are the likeliest explanation for their markedly different global epidemiology.
Genetic and phylogenetic analysis of HIV type 1 env subtypes in Ghana, west Africa.
HIV-1 genetic variation among 19 HIV-1-infected people of mean age 34.5 years living in Accra, Akwatia, Kumasi, and Ho, in Ghana and a cocirculation of subtypes A, D, and G was identified.
Genetic variability of HIV type 1 in Kenya.
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Isolation and envelope sequence of a highly divergent HIV-1 isolate: definition of a new HIV-1 group.
Phylogenetic analysis of the isolation and envelope sequence of a divergent HIV-1 isolate from a French woman with AIDS reveals that the three viruses are equidistant from one another and that their mutual divergence is similar to what has been reported between the more conventional HIV- 1 subtypes.
Genetic variants of HIV-1 in Thailand.
Results of genetic characterization of 16 HIV-1 isolates from Thailand using a combination of polymerase chain reaction (PCR) typing and DNA sequencing indicate both general and specific features that distinguish the Northern Thailand variant both from the Bangkok variant and from virtually all previously sequenced HIV- 1 isolates.
Genotypic subtypes of HIV‐1 in Cameroon
Findings on a limited number of viruses suggest extensive env gene diversity of HIV-1 strains from Cameroon, and could have implications for vaccine development in Africa.