The putative tumor suppressor miR-524-5p directly targets Jagged-1 and Hes-1 in glioma.

Abstract

Notch pathway plays critical role in stem cell maintenance and angiogenesis, as well as cell fate decisions of cancer. However, concrete mechanisms of notch pathway regulation in glioma were not well known, especially mediated by microRNAs. In this study, we identified a brain-specific miRNA, miR-524-5p, which was associated with the pathological grade and… (More)
DOI: 10.1093/carcin/bgs261

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