The putative pore-forming domain of Bax regulates mitochondrial localization and interaction with Bcl-X(L).

@article{Nouraini2000ThePP,
  title={The putative pore-forming domain of Bax regulates mitochondrial localization and interaction with Bcl-X(L).},
  author={Shahrzad Nouraini and Emmanuelle Six and Shigemi Matsuyama and Stan Stanislaw Krajewski and John C. Reed},
  journal={Molecular and cellular biology},
  year={2000},
  volume={20 5},
  pages={1604-15}
}
Bax is a proapoptotic member of the Bcl-2 family of proteins which localizes to and uses mitochondria as its major site of action. Bax normally resides in the cytoplasm and translocates to mitochondria in response to apoptotic stimuli, and it promotes apoptosis in two ways: (i) by disrupting mitochondrial membrane barrier function by formation of ion-permeable pores in mitochondrial membranes and (ii) by binding to antiapoptotic Bcl-2 family proteins via its BH3 domain and inhibiting their… CONTINUE READING

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ApoptosisProcess involves geneBCL2 gene
Bax normally resides in the cytoplasm and translocates to mitochondria in response to apoptotic stimuli , and it promotes apoptosis in two ways : ( i ) by disrupting mitochondrial membrane barrier function by formation of ion - permeable pores in mitochondrial membranes and ( ii ) by binding to antiapoptotic Bcl-2 family proteins via its BH3 domain and inhibiting their functions .
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