The putative phosphoinositide-specific phospholipase C gene, PLC1, of the yeast Saccharomyces cerevisiae is important for cell growth.

@article{Yokoo1993ThePP,
  title={The putative phosphoinositide-specific phospholipase C gene, PLC1, of the yeast Saccharomyces cerevisiae is important for cell growth.},
  author={Takehiko Yoko-o and Yasushi Matsui and Hitoshi Yagisawa and Hideaki Nojima and Isao Uno and Akio Toh-E},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1993},
  volume={90 5},
  pages={
          1804-8
        }
}
Using the polymerase chain reaction technique, we have isolated a gene that encodes a putative phosphoinositide-specific phospholipase C (PLC) in the yeast Saccharomyces cerevisiae. The nucleotide sequence indicates that the gene encodes a polypeptide of 869 amino acid residues with a calculated molecular mass of 101 kDa. This polypeptide has both the X and Y regions conserved among mammalian PLC-beta, -gamma, and -delta, and the structure is most similar to that of mammalian PLC-delta. This… CONTINUE READING
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