The putative oncogene GASC1 demethylates tri- and dimethylated lysine 9 on histone H3

@article{Cloos2006ThePO,
  title={The putative oncogene GASC1 demethylates tri- and dimethylated lysine 9 on histone H3},
  author={Paul A. C. Cloos and Jesper Heile Christensen and Karl Agger and Alessio Maiolica and Juri Rappsilber and Torben L Antal and Klaus H. Hansen and Kristian Helin},
  journal={Nature},
  year={2006},
  volume={442},
  pages={307-311}
}
Methylation of lysine and arginine residues on histone tails affects chromatin structure and gene transcription. Tri- and dimethylation of lysine 9 on histone H3 (H3K9me3/me2) is required for the binding of the repressive protein HP1 and is associated with heterochromatin formation and transcriptional repression in a variety of species. H3K9me3 has long been regarded as a ‘permanent’ epigenetic mark. In a search for proteins and complexes interacting with H3K9me3, we identified the protein… 

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