The putative coiled coil domain of the phi 29 terminal protein is a major determinant involved in recognition of the origin of replication.

@article{SernaRico2000ThePC,
  title={The putative coiled coil domain of the phi 29 terminal protein is a major determinant involved in recognition of the origin of replication.},
  author={Alejandro Serna-Rico and Belen Illana and M. Salas and Wilfried J J Meijer},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 51},
  pages={40529-38}
}
The linear double-stranded genome of phage phi29 contains a terminal protein (TP) covalently linked at each 5' DNA end, called parental TP. Initiation of phi29 DNA replication starts with the recognition of the origins of replication, constituted by the parental TP-containing DNA ends, by a heterodimer containing phi29 DNA polymerase and primer TP. It has been argued that origin recognition involves protein-protein interactions between parental and primer TP. Analysis of the TP sequence… CONTINUE READING

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