The putative cannabinoid receptor GPR55 plays a role in mechanical hyperalgesia associated with inflammatory and neuropathic pain

@article{Staton2008ThePC,
  title={The putative cannabinoid receptor GPR55 plays a role in mechanical hyperalgesia associated with inflammatory and neuropathic pain},
  author={P. C. Staton and J. Hatcher and D. J. Walker and A. Morrison and I. Chessell},
  journal={PAIN},
  year={2008},
  volume={139},
  pages={225-236}
}
  • P. C. Staton, J. Hatcher, +2 authors I. Chessell
  • Published 2008
  • Chemistry, Medicine
  • PAIN
  • Abstract It has been postulated that the G protein‐coupled receptor, GPR55, is a third cannabinoid receptor. Given that the ligands at the CB1 and CB2 receptors are effective analgesic and anti‐inflammatory agents, the role of GPR55 in hyperalgesia associated with inflammatory and neuropathic pain has been investigated. As there are no well‐validated GPR55 tool compounds, a GPR55 knockout (GPR55−/−) mouse line was generated and fully backcrossed onto the C57BL/6 strain. General phenotypic… CONTINUE READING
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