The putative cancer stem cell marker USP22 is a subunit of the human SAGA complex required for activated transcription and cell-cycle progression.

@article{Zhang2008ThePC,
  title={The putative cancer stem cell marker USP22 is a subunit of the human SAGA complex required for activated transcription and cell-cycle progression.},
  author={Xiao-yong Zhang and Maya Varthi and Stephen M. Sykes and Charles Phillips and Claude Warzecha and Wenting Zhu and Anastasia Wyce and Alan W. Thorne and Shelley L Berger and Steven B. McMahon},
  journal={Molecular cell},
  year={2008},
  volume={29 1},
  pages={102-11}
}
Polycomb genes encode critical regulators of both normal stem cells and cancer stem cells. A gene signature that includes Polycomb genes and additional genes coregulated with Polycomb genes was recently identified. The expression of this signature has been reported to identify tumors with the cancer stem cell phenotypes of aggressive growth, metastasis, and therapy resistance. Most members of this 11 gene signature encode proteins with well-defined roles in human cancer. However, the function… CONTINUE READING
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